• Surviving Sepsis

    Surviving Sepsis

    by preventing septic shock
    Septic shock is still the leading cause of death in intensive care units -
    despite antimicrobial and resuscitation attempts
  • Adrenomedullin

    Adrenomedullin

    Essential player in septic shock
    The vasoactive hormone is highly elevated during sepsis progression
    and is the strongest known predictor of circulatory breakdown and death
  • Adrecizumab

    Adrecizumab

    First-in-class sepsis therapy
    The humanized monoclonal anti-ADM antibody modulates Adrenomedullin
    activity and improves all relevant end points in preclinical sepsis models

Our Mission: Surviving Sepsis

8,000,000 people die from sepsis each year worldwide. Adrenomed's aim is to prevent the fatal septic shock by targeting the vasoactive hormone Adrenomedullin, an essential player in the onset of septic shock. Our first-in-class drug candidate Adrecizumab is a humanized monoclonal anti-Adrenomedullin antibody that is currently in clinical phase I.

 

Recent Publications

Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Alexandre Mebazaa, Pierre François Laterre, James A. Russell, Andreas Bergmann, Luciano Gattinoni, Etienne Gayat, Michael O. Harhay, Oliver Hartmann, Frauke Hein, Anne Louise Kjolbye, Matthieu Legrand, Roger J. Lewis, John C. Marshall, Gernot Marx, Peter Radermacher, Mathias Schroedter, Paul Scigalla, Wendy Gattis Stough, Joachim Struck, Greet Van den Berghe, Mehmet Birhan Yilmaz and Derek C. Angus, Journal of Intensive Care 2016, 4:24 PDF | PubMed

Hemodynamics effects of Adrecizumab in sepsis rat

Blet A, Sadoune M , Polidano E , Merval R, Bernard C , Samuel JL and Mebazaa A, Intensive Care Medicine Experimental, 2015, 3(Suppl 1):A618 | PDF

Endothelial Barrier Injury is directly related to Kidney Dysfunction in resuscitated murine shock model

Zink F, Stenzel T, Wachter U, Vogt J, McCook O, Radermacher P.,  Shock 2015, 44 Suppl 2:15-6. | Website | F1000Prime

Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis

Rossella Marino, Joachim Struck, Alan S Maisel, Laura Magrini, Andreas Bergmann and Salvatore Di Somma, Critical Care 2014, 18(1):R34 | PDF | PubMed

Adrenomedullin: it's double-edged sword during sepsis slices yet again

Kox M, Pickkers P, (Editorial) Intensive Care Medicine Experimental, 2014, 2:1 | PDF

Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

Katja Wagner, Ulrich Wachter, Josef A Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher, Florian Wagner, Intensive Care Medicine Experimental 2013, 1:2 | PDF | PubMed

Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Joachim Struck, Frauke Hein, Siegmund Karasch, Andreas Bergmann, Intensive Care Medicine Experimental 2013, 1:3 PDF | PubMed